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121345-64-0
for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week
1190378-57-4
Formula: C16H26N2O2S
Smiles: CC(C)(C)NC(=O)NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C1C(Cl)=CC=CC=1Cl
PI-3065 Catalog No.:M8668-10 121345-64-0PI3065 is a p110 isoform of phosphoinositide 3 OH kinase (PI(3)K) inhibitor. Inhibitors against the p110 isoform of phosphoinositide 3 OH kinase (PI(3)K) have shown remarkable therapeutic efficacy in some human leukaemias. As p110 is primarily expressed in leukocytes, drugs against p110 have not been considered for the treatment of solid tumours. p110 inactivation in regulatory T cells unleashes CD8(+) cytotoxic T cells and induces tumour regression.
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